134 research outputs found
Quantum Statistical Mechanics of Dissolving Vortices
The quantum partition function for dissolving Abelian Higgs vortices is
calculated explicitly, using spectral data for the Beltrami Laplacian on the
-vortex moduli space with a scaled Fubini--Study metric.
From the partition function, the pressure of the vortex gas is derived. There
are three asymptotic regimes -- High, Intermediate and Low Temperature. The
phase crossover from Intermediate to Low Temperature is modelled by a Bessel
function. In the Low Temperature regime the free energy is not extensive but is
proportional to .Comment: 12 pages, 7 figure
SaccadeNet: A Fast and Accurate Object Detector
Object detection is an essential step towards holistic scene understanding.
Most existing object detection algorithms attend to certain object areas once
and then predict the object locations. However, neuroscientists have revealed
that humans do not look at the scene in fixed steadiness. Instead, human eyes
move around, locating informative parts to understand the object location. This
active perceiving movement process is called \textit{saccade}.
%In this paper, Inspired by such mechanism, we propose a fast and accurate
object detector called \textit{SaccadeNet}. It contains four main modules, the
\cenam, the \coram, the \atm, and the \aggatt, which allows it to attend to
different informative object keypoints, and predict object locations from
coarse to fine. The \coram~is used only during training to extract more
informative corner features which brings free-lunch performance boost. On the
MS COCO dataset, we achieve the performance of 40.4\% mAP at 28 FPS and 30.5\%
mAP at 118 FPS. Among all the real-time object detectors, %that can run faster
than 25 FPS, our SaccadeNet achieves the best detection performance, which
demonstrates the effectiveness of the proposed detection mechanism
Resolving singular forces in cavity flow: Multiscale modeling from atoms to millimeters
A multiscale approach for fluid flow is developed that retains an atomistic
description in key regions. The method is applied to a classic problem where
all scales contribute: The force on a moving wall bounding a fluid-filled
cavity. Continuum equations predict an infinite force due to stress
singularities. Following the stress over more than six decades in length in
systems with characteristic scales of millimeters and milliseconds allows us to
resolve the singularities and determine the force for the first time. The
speedup over pure atomistic calculations is more than fourteen orders of
magnitude. We find a universal dependence on the macroscopic Reynolds number,
and large atomistic effects that depend on wall velocity and interactions.Comment: 4 pages,3 figure
Dynamics of Freely Cooling Granular Gases
We study dynamics of freely cooling granular gases in two-dimensions using
large-scale molecular dynamics simulations. We find that for dilute systems the
typical kinetic energy decays algebraically with time, E(t) ~ t^{-1}, in the
long time limit. Asymptotically, velocity statistics are characterized by a
universal Gaussian distribution, in contrast with the exponential high-energy
tails characterizing the early homogeneous regime. We show that in the late
clustering regime particles move coherently as typical local velocity
fluctuations, Delta v, are small compared with the typical velocity, Delta v/v
~ t^{-1/4}. Furthermore, locally averaged shear modes dominate over acoustic
modes. The small thermal velocity fluctuations suggest that the system can be
heuristically described by Burgers-like equations.Comment: 4 pages, 5 figure
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19
HSPA5 (BiP, GRP78) has been reported as a potential host-cell receptor for SARS-Cov-2, but its expression profiles on different tissues including tumors, its susceptibility to SARS-Cov-2 virus and severity of its adverse effects on malignant patients are unclear. In the current study, HSPA5 has been found to be expressed ubiquitously in normal tissues and significantly increased in 14 of 31 types of cancer tissues. In lung cancer, mRNA levels of HSPAS were 253-fold increase than that of ACE2. Meanwhile, in both malignant tumors and matched normal samples across almost all cancer types, mRNA levels of HSPAS were much higher than those of ACE2. Higher expression of HSPAS significantly decreased patient overall survival (OS) in 7 types of cancers. Moreover, systematic analyses found that 7.15% of 5,068 COVID-19 cases have malignant cancer coincidental situations, and the rate of severe events of COVID-19 patients with cancers present a higher trend than that for all COVID-19 patients, showing a significant difference (33.33% vs 16.09%, p<0.01). Collectively, these data imply that the tissues with high HSPA5 expression, not low ACE2 expression, are susceptible to be invaded by SARS-CoV-2. Taken together, this study not only indicates the clinical significance of HSPA5 in COVID-19 disease and cancers, but also provides potential clues for further medical treatments and managements of COVID-19 patients
Statistics of Dissipation and Enstrophy Induced by a Set of Burgers Vortices
Dissipation and enstropy statistics are calculated for an ensemble of
modified Burgers vortices in equilibrium under uniform straining. Different
best-fit, finite-range scaling exponents are found for locally-averaged
dissipation and enstrophy, in agreement with existing numerical simulations and
experiments. However, the ratios of dissipation and enstropy moments supported
by axisymmetric vortices of any profile are finite. Therefore the asymptotic
scaling exponents for dissipation and enstrophy induced by such vortices are
equal in the limit of infinite Reynolds number.Comment: Revtex (4 pages) with 4 postscript figures included via psfi
MXene-Integrated Silk Fibroin-Based Self-Assembly-Driven 3D-Printed Theragenerative Scaffolds for Remotely Photothermal Anti-Osteosarcoma Ablation and Bone Regeneration
Aiming to address the bone regeneration and cancer therapy functionalities in one single material, in this study, we developed a dual-functional theragenerative three-dimensional (3D) aerogel-based composite scaffold from hybridization of photo-cross-linked silk fibroin (SF) biopolymer with MXene (Ti3C2) two-dimensional (2D) nanosheets. To fabricate the scaffold, we first develop a dual-cross-linked SF-based aerogel scaffold through 3D printing and photo-cross-linking of the self-assembly-driven methacrylate-modified SF (SF-MA) gel with controlled pore size, macroscopic geometry, and mechanical stability. In the next step, to endow a remotely controlled photothermal antiosteosarcoma ablation function to fabricated aerogel scaffold, MXene 2D nanosheets with strong near-infrared (NIR) photon absorption properties were integrated into the 3D-printed scaffolds. While 3D-printed MXene-modified dual-cross-linked SF composite scaffolds can mediate the in vitro growth and proliferation of preosteoblastic cell lines, they also endow a strong photothermal effect upon remote irradiation with NIR laser but also significantly stimulate bone mineral deposition on the scaffold surface. Additionally, besides the local release of the anticancer model drug, the generated heat (45-53 ?) mediated the photothermal ablation of cancer cells. The developed aerogel-based composites and chosen therapeutic techniques are thought to render a significant breakthrough in biomaterials' future clinical applications
Relative dispersion in fully developed turbulence: The Richardson's Law and Intermittency Corrections
Relative dispersion in fully developed turbulence is investigated by means of
direct numerical simulations. Lagrangian statistics is found to be compatible
with Richardson description although small systematic deviations are found. The
value of the Richardson constant is estimated as , in a close
agreement with recent experimental findings [S. Ott and J. Mann J. Fluid Mech.
{\bf 422}, 207 (2000)]. By means of exit-time statistics it is shown that the
deviations from Richardson's law are a consequence of Eulerian intermittency.
The measured Lagrangian scaling exponents require a set of Eulerian structure
function exponents which are remarkably close to standard ones
known for fully developed turbulence
Social Determinants of Community Health Services Utilization among the Users in China: A 4-Year Cross-Sectional Study
Background To identify social factors determining the frequency of community health service (CHS) utilization among CHS users in China. Methods Nationwide cross-sectional surveys were conducted in 2008, 2009, 2010, and 2011. A total of 86,116 CHS visitors selected from 35 cities were interviewed. Descriptive analysis and multinomial logistic regression analysis were employed to analyze characteristics of CHS users, frequency of CHS utilization, and the socio-demographic and socio-economic factors influencing frequency of CHS utilization. Results Female and senior CHS clients were more likely to make 3–5 and ≥6 CHS visits (as opposed to 1–2 visits) than male and young clients, respectively. CHS clients with higher education were less frequent users than individuals with primary education or less in 2008 and 2009; in later surveys, CHS clients with higher education were the more frequent users. The association between frequent CHS visits and family income has changed significantly between 2008 and 2011. In 2011, income status did not have a discernible effect on the likelihood of making ≥6 CHS visits, and it only had a slight effect on making 3–5 CHS visits. Conclusion CHS may play an important role in providing primary health care to meet the demands of vulnerable populations in China. Over time, individuals with higher education are increasingly likely to make frequent CHS visits than individuals with primary school education or below. The gap in frequency of CHS utilization among different economic income groups decreased from 2008 to 2011
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